May localize in: Spleen, Liver, Bone marrow, Joints, Reproductive organs. Severity in humans: B. melitensis>B. suis>B. abortus >B. canis, others. Symptoms-Humans: Common symptoms include Malaise, Insomnia, Anorexia, Headache, Arthralgia, Constipation, sexual impotence, nervousness, depression. (Acha et al., 2003)